Neuroinflammation and Psychiatric Disorders

Neuroinflammation plays a central role in the pathophysiology of depression, schizophrenia, bipolar disorder, and cognitive disorders. Activated microglia and elevated pro-inflammatory cytokines such as IL-6, TNF-alpha, and CRP are associated with neuronal damage, synaptic dysfunction, and impaired neurotransmission. Chronic inflammation affects neurogenesis in the hippocampus, contributing to cognitive deficits and mood dysregulation. Neuroimaging techniques, including PET scans, allow visualization of microglial activation and inflammatory burden in the brain. Lifestyle factors such as diet, stress, sleep, and physical activity modulate neuroinflammation, influencing psychiatric outcomes. Pharmacological interventions targeting inflammatory pathways, such as cytokine modulators and omega-3 fatty acids, are under investigation for therapeutic potential. AI-driven predictive models can integrate clinical, genetic, and inflammatory biomarkers to identify individuals at risk for inflammation-related psychiatric disorders. Telecommunication-enabled remote monitoring of physiological and behavioral indicators allows continuous tracking of neuroinflammatory impact, enabling early intervention and personalized treatment strategies. Understanding neuroinflammation provides a biological framework for linking immune dysregulation to psychiatric morbidity and guides development of targeted interventions.

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