Addiction and Substance Use Disorders

Addiction involves chronic dysregulation of the mesolimbic dopamine pathway, leading to compulsive reward-seeking behavior and impaired inhibitory control. Substance use, including alcohol, opioids, and stimulants, alters synaptic plasticity, receptor density, and neurotransmitter signaling. Genetic predisposition interacts with environmental factors and epigenetic modifications, affecting vulnerability. Neuroimaging studies reveal prefrontal cortex hypoactivity and heightened striatal responses in addicted individuals. AI algorithms can predict relapse risk by analyzing behavioral patterns, physiological biomarkers, and digital activity. Telecommunication-based interventions, such as mobile apps and teletherapy, facilitate monitoring, counseling, and adherence to treatment. Pharmacological approaches target dopaminergic, glutamatergic, and GABAergic pathways to restore neurochemical balance. Combining biological, behavioral, and digital strategies enables personalized, precise management of addiction and improves long-term recovery outcomes.

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